Soy isoflavone linked to blood pressure improvements

Genistein, an isoflavone from soy, may stimulate the expression of an enzyme linked to better blood flow, suggests a new animal study that my have implications for high blood pressure in humans. «Our data suggest that genistein has direct genomic effects on the vascular wall that are unrelated to its known actions, leading to increased eNOS expression and NO synthesis, thereby improving hypertension,» wrote Hongwei Si and Dongmin Liu from Virginia Polytechnic Institute and State University. The researchers report that the isoflavone enhanced the expression of eNOS by 1.8 to 2.6-fold of control, and the subsequent synthesis of NO in both HAEC and HUVEC when used in doses between one and 10 micromoles per litre. These concentrations are «physiologically achievable concentrations in individuals consuming soy products,» they said. When the rats were supplemented with genistein, the researchers observed a restoration of eNOS levels in the aorta, in addition to improvements in aortic wall thickness. The hypertension of the animals was eased, wrote Si and Liu. The research adds and expands the science linking isoflavones to improvements in cardiovascular health. Previously, studies have reported improvements in blood cholesterol levels, and easing blood clotting.
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Source: NutraIngredients