Vit E may protect male smokers from oxidative stress: study

A diet rich in vitamin E could protect smokers from the oxidative stress linked to cancer development, US-based scientists reported this week. «This suggests that while working toward the goal of quitting smoking, which is the very best way to prevent development of smoking-related cancers, it could be helpful to eat a diet rich in vitamin E,» said Frederica Perera, senior investigator from Columbia University School of Public Health. «We don’t yet know why this relationship was not found in women, but a good diet is beneficial to health in many ways.» Vitamin E, an antioxidant, actually refers to a group of eight compounds: four types of tocopherols and four tocotrienols. The most common form consumed in the American diet is gamma-tocopherol, while alpha-tocopherol is the form mostly found in supplements. Perera and colleagues reported that increased plasma alpha-tocopherol levels were associated with lower levels of oxidative damage, according to 8-OHdG levels, but only among men. The data was presented at the American Association for Cancer Research’s Frontiers in Cancer Prevention Research meeting earlier this week. The researchers also investigated possible interactions between vitamin E and GSTM1, a gene variant known to produce enzymes that efficiently detoxify carcinogens in tobacco smoke. The apparent protective effect of vitamin E was greatest among the men with the GSTM1 gene variant, said the researchers. A diet rich in antioxidants like vitamins C and E, and beta-carotene has been reported to protect certain sub-populations, particularly smokers, against prostate cancer, a disease that is becoming more common, with incidence rates haven risen by almost two per cent over 15 years. Indeed, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, (Journal of the National Cancer Institute, Vol. 98, pp. 245-254), and the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) study (1998), have both reported protective effects of vitamin E against prostate cancer amongst smokers.
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Source: NutraIngredients