Synergistic cancer effect of lycopene with vitamin

June-2006 The combination of lycopene and vitamin E has been shown to be far more effective in inhibiting the growth of prostate cancer than the effect of lycopene alone, according to new research from BASF. A phase-2 clinical trial on humans is under way, but initial results with mice, published in the May issue of the Journal of Nutrition are encouraging Tumour suppression was increased 73% (compared to 53% for lycopene alone) and survival time increased by 40% (19% for lycopene alone) in a study carried out by the urology department of the Erasmus University in Rotterdam, the Netherlands. BASF investigated how different doses of lycopene and vitamin E affect prostate tumour growth, and whether a combination of the two exerts additional effects. The PSA (prostate-specific antigen) levels in blood ? a marker for tumour growth ? were also monitored. Combined treatments using comparatively low dosage ? just 5mg/kg body weight for each product ? was shown to be most effective. PSA levels were proportional to tumour size, regardless of the dietary supplementation received, indicating that supplements of lycopene and vitamin E are unlikely to interfere with PSA measurements for diagnostic purposes.
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Source: Ingredients, Health & Nutrition